Description

1,1,1-Trifluoro-4-Iodobutane is a versatile fluorinated organic building block characterized by its terminal iodine and trifluoromethyl groups. This compound is highly valued in advanced chemical synthesis for introducing fluorinated alkyl chains and serving as a key intermediate in cross-coupling reactions. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors who require precise fluorination to modify compound properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs) with enhanced metabolic stability and bioavailability via the trifluoromethyl group.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and pesticides where fluorine atoms improve efficacy and environmental persistence.
• Material Science: Serves as a precursor for fluorinated polymers, liquid crystals, and specialty surfactants with unique surface properties and chemical resistance.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions (e.g., Negishi, Suzuki) to construct complex organic molecules.
• Fluorine Chemistry Research: A critical reagent in academic and industrial R&D for studying new fluorination methodologies and reaction pathways.
• Ligand and Catalyst Development: Used to synthesize fluorinated ligands for catalysis, potentially enhancing reaction selectivity and efficiency.

Basic Information

Product Name	1,1,1-Trifluoro-4-Iodobutane
CAS No.	461-17-6
Molecular Formula	C4H6F3I
Molecular Weight	237.99 g/mol
Synonyms	4-Iodo-1,1,1-trifluorobutane; 1,1,1-Trifluoro-4-iodobutane; 4-Iodobutyl trifluoride; Butane, 1,1,1-trifluoro-4-iodo-; Trifluoro(4-iodobutyl); Iodotrifluorobutane
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoro-4-Iodobutane is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to verify identity, potency, and impurity profiles. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile and light-sensitive nature, it is recommended to store the product at controlled room temperature (15-25°C) under an inert atmosphere for extended shelf life.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.8 g/mL
Boiling Point	~145-150°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.