Description

2-(Trifluoromethyl)Acetamide is a versatile fluorinated organic compound that serves as a critical building block in advanced chemical synthesis. Its unique trifluoromethyl group imparts valuable properties such as enhanced metabolic stability and lipophilicity, making it indispensable for creating high-performance materials and active ingredients. This intermediate is primarily sought by the pharmaceutical, agrochemical, and specialty chemical industries for research and development as well as commercial-scale production.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, where the CF₃ group improves biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, enhancing their dielectric anisotropy and stability.
• Polymer & Resin Modifier: Incorporated to introduce fluorine into polymer chains, improving chemical resistance, thermal stability, and surface properties of high-performance plastics and coatings.
• Organic Synthesis Building Block: Employed in cross-coupling reactions, amide bond formations, and as a precursor for other trifluoromethylated heterocycles and fine chemicals.
• Research & Development: A valuable compound for medicinal chemistry and material science research in academic and industrial laboratories.

Basic Information

Product Name	2-(Trifluoromethyl)Acetamide
CAS No.	460-75-3
Molecular Formula	C₃H₄F₃NO
Molecular Weight	127.07 g/mol
Synonyms	2,2,2-Trifluoroacetamide; α,α,α-Trifluoroacetamide; Trifluoroacetamide; TFA Amide; 2-(Trifluoromethyl)ethanamide; NSC 9235; Perfluoroacetamide; CF₃CONH₂
EINECS	207-310-0

Quality Control

Our 2-(Trifluoromethyl)Acetamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP and ISO 9001 standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Melting Point	74 - 78 °C
Heavy Metals	≤10 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.