Description

2-Chloro-4'-Fluoroacetophenone is a versatile and high-purity organic building block, specifically a halogenated acetophenone derivative, essential for advanced chemical synthesis. Its value lies in its dual functional groups, which make it a critical intermediate for constructing complex molecules in regulated industries. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of various active pharmaceutical ingredients (APIs), particularly those with fluorinated or chlorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging its halogenated structure for bioactivity.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated organic compounds used in electronic displays and optoelectronics.
• Organic Synthesis Building Block: Employed in Friedel-Crafts acylation, nucleophilic substitution, and cross-coupling reactions to introduce the 2-chloro-4-fluorophenylacetyl moiety.
• Chemical Research & Development: Utilized in academic and industrial R&D labs for method development and creating novel chemical entities.
• Dye & Pigment Intermediate: Acts as a precursor in the manufacture of specialized dyes and pigments requiring halogenated aromatic ketones.

Basic Information

Product Name	2-Chloro-4'-Fluoroacetophenone
CAS No.	456-04-2
Molecular Formula	C8H6ClFO
Molecular Weight	172.58 g/mol
Synonyms	1-(4-Fluorophenyl)-2-chloroethanone; 2-Chloro-1-(4-fluorophenyl)ethanone; 4'-Fluoro-2-chloroacetophenone; p-Fluoro-ω-chloroacetophenone; 2-Chloro-4-fluoroacetophenone; α-Chloro-4'-fluoroacetophenone; 4-Fluorophenacyl chloride; NSC 406913
EINECS	Contact for details

Quality Control

Our 2-Chloro-4'-Fluoroacetophenone is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber or otherwise opaque.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Loss on Drying	≤0.5%
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.