Description

Trifluoroacetic Acid:Triethylamine 2M:2 is a pre-mixed reagent system combining a strong fluorinated organic acid with a tertiary amine base, commonly used as a versatile deprotection and coupling agent. This ready-to-use formulation offers significant advantages in process consistency, safety, and handling efficiency for demanding synthetic workflows. It is an essential reagent for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for peptide synthesis and the manipulation of base-sensitive compounds.

Application

• Peptide Synthesis: Primarily used as a highly effective cleavage and deprotection cocktail for removing t-butyl (t-Boc) and other acid-labile protecting groups from solid-phase synthesized peptides.
• Oligonucleotide Synthesis: Employed in the deprotection step for removing cyanoethyl phosphate protecting groups during DNA/RNA synthesis.
• Pharmaceutical Intermediates: Facilitates key deprotection and cyclization reactions in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Polymer Chemistry: Acts as a catalyst or reagent in polymerization processes and the modification of polymer side chains.
• Organic Synthesis: Serves as a potent acid catalyst and solvent system for esterifications, rearrangements, and other acid-mediated transformations.
• Analytical Chemistry: Used as a mobile phase modifier in High-Performance Liquid Chromatography (HPLC) for separating complex mixtures, particularly peptides and proteins.

Basic Information

Product Name	Trifluoroacetic Acid:Triethylamine 2M:2
CAS No.	454-49-9
Molecular Formula	C2HF3O2 • C6H15N (Mixture)
Molecular Weight	114.02 (TFA) • 101.19 (TEA) (Mixture)
Synonyms	TFA:TEA 2M:2; Trifluoroacetic Acid - Triethylamine Mixture; Triethylammonium Trifluoroacetate Solution; TFA/TEA Deprotection Cocktail; Cleavage Cocktail B; Trifluoroacetic Acid Triethylamine Salt; 2M:2 TFA/TEA; Peptide Synthesis Cleavage Reagent
EINECS	Contact for details

Quality Control

Our Trifluoroacetic Acid:Triethylamine 2M:2 reagent is manufactured under strict quality control protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot is analyzed to confirm the precise molar ratio, purity, and absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing assay, identification, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area at room temperature (15-25°C). Due to the presence of a strong acid and volatile components, ensure containers are kept upright and away from heat, sparks, and open flame. Use appropriate corrosion-resistant storage cabinets.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectra for TFA and TEA
Assay (TFA & TEA by Titration)	2.0M ± 0.1M : 2.0M ± 0.1M
Water Content (KF)	≤ 0.5%
Related Impurities (HPLC)	Meets internal standards

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.