Description

Ethyl Difluoroacetate is a versatile fluorinated ester building block of significant importance in advanced organic synthesis. Its value lies in the introduction of the difluoromethyl group, a key motif for modulating the physicochemical and metabolic properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors seeking to develop novel compounds with enhanced stability and bioavailability.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing difluoromethyl ether or difluoromethylamine groups.
• Agrochemical Synthesis: Used in the development of modern pesticides and herbicides, where the difluoroacetate moiety can improve efficacy and environmental profile.
• Fluorinated Material Precursor: Serves as a starting material for synthesizing fluorinated polymers, liquid crystals, and other advanced materials with unique properties.
• Organic Synthesis Reagent: Employed in various reactions, including esterifications, alkylations, and as a difluoromethyl anion equivalent in carbon-carbon bond formation.
• Life Science Research: Utilized in medicinal chemistry and drug discovery programs for structure-activity relationship (SAR) studies and probe molecule development.

Basic Information

Product Name	Ethyl Difluoroacetate
CAS No.	454-31-9
Molecular Formula	C4H6F2O2
Molecular Weight	124.09 g/mol
Synonyms	Difluoroacetic Acid Ethyl Ester; Ethyl 2,2-Difluoroacetate; 2,2-Difluoroacetic Acid Ethyl Ester; Ethyl α,α-Difluoroacetate; EDFA; Ethyl Esters, difluoroacetate; Acetic acid, 2,2-difluoro-, ethyl ester
EINECS	207-231-8

Quality Control

Our Ethyl Difluoroacetate is produced and tested under a strict quality management system. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure it meets the high-purity standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.