Description

1,3-Difluoroacetone (CAS NO 453-14-5) is a versatile fluorinated building block essential for advanced organic synthesis. Its unique structure, featuring two reactive fluorine atoms adjacent to a carbonyl group, makes it a critical intermediate for introducing difluoroacetone motifs into complex molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the synthesis of fluorinated drug candidates, particularly in protease inhibitors and kinase modulators.
• Agrochemical Synthesis: Used in creating novel fluorinated pesticides and herbicides with enhanced activity and environmental profile.
• Material Science: Serves as a precursor for fluorinated polymers, coatings, and liquid crystals with unique thermal and chemical resistance.
• Organic Synthesis Building Block: Employed in nucleophilic substitution and condensation reactions to construct complex heterocycles and aliphatic chains.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new fluorination methodologies and reaction pathways.

Basic Information

Product Name	1,3-Difluoroacetone
CAS No.	453-14-5
Molecular Formula	C3H4F2O
Molecular Weight	94.06 g/mol
Synonyms	1,3-Difluoro-2-propanone; Difluoroacetone; 1,3-Difluoroacetone; 1,1-Difluoro-3-oxopropane; 2-Propanone, 1,3-difluoro-; F2Ac; α,γ-Difluoroacetone
EINECS	Contact for details

Quality Control

Our 1,3-Difluoroacetone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatography and spectroscopy, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We support compliance with relevant regulatory frameworks for research and industrial use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place, away from heat sources and incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed and at a consistent temperature, ideally between 2°C and 8°C for extended stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.