Description

Ethanone, 2-Chloro-2-Fluoro-1-Phenyl- (9Ci) CAS NO 447-15-4 is a specialized fluorinated and chlorinated aromatic ketone, serving as a versatile and high-value building block in advanced organic synthesis. Its unique structure, featuring both halogen substituents on the α-carbon, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to introduce fluorinated motifs that can dramatically alter a compound's bioavailability, stability, and activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic systems to enhance metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atom improves lipophilicity and biological activity.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its ability to modify electronic properties and intermolecular interactions.
• Fluorination Reagent Precursor: Can be utilized to develop or study new fluorination methodologies in organic chemistry research.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological processes, leveraging the distinct properties of the fluorine atom.

Basic Information

Product Name	Ethanone, 2-Chloro-2-Fluoro-1-Phenyl- (9Ci)
CAS No.	447-15-4
Molecular Formula	C8H6ClFO
Molecular Weight	172.58 g/mol
Synonyms	2-Chloro-2-fluoroacetophenone; α-Chloro-α-fluoroacetophenone; 2-Fluoro-2-chloro-1-phenylethanone; 1-Phenyl-2-chloro-2-fluoroethanone; 447-15-4; NSC 406079; 2-Chloro-2-fluoro-1-phenylethanone; (Chlorofluoromethyl) phenyl ketone
EINECS	207-177-1

Quality Control

Our Ethanone, 2-Chloro-2-Fluoro-1-Phenyl- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistent performance. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our commitment to quality supports applications in cGMP-compliant environments and advanced research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to strong alkalis and fluorides; keep away from incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.