Description

4'-Fluoro-2'-Methyacetophenone is a specialized fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its value lies in its unique molecular structure, which combines a reactive acetyl group with fluorine and methyl substituents on the aromatic ring, enabling precise modifications for creating complex molecules. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated organic electronic materials due to its ability to influence molecular polarity and packing.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with specific thermal or chemical resistance properties.
• Organic Synthesis & Catalysis Research: Employed in methodological studies and as a model substrate for developing new fluorination or cross-coupling reactions.
• Flavor & Fragrance Ingredient Synthesis: Acts as an intermediate for creating complex aromatic molecules used in high-value fragrance compositions.

Basic Information

Product Name	4'-Fluoro-2'-Methyacetophenone
CAS No.	446-29-7
Molecular Formula	C9H9FO
Molecular Weight	152.17 g/mol
Synonyms	1-(4-Fluoro-2-methylphenyl)ethanone; 4'-Fluoro-2'-methylacetophenone; 2-Methyl-4-fluoroacetophenone; 4-Fluoro-2-methylacetophenone; 1-Acetyl-4-fluoro-2-methylbenzene; p-Fluoro-o-methylacetophenone; 2-Methyl-4-fluoroacetophenone; 4-Fluoro-2-methylphenyl methyl ketone
EINECS	Contact for details

Quality Control

Our 4'-Fluoro-2'-Methyacetophenone is produced under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, documenting all critical parameters. Our quality system is designed to meet the stringent requirements of cGMP for pharmaceutical intermediates and supports compliance with global regulatory standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.