Description

2'-Fluoro-5'-Methylacetophenone is a specialized fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its value lies in the strategic placement of fluorine and methyl substituents on the acetophenone core, which allows for precise modulation of electronic and steric properties in target molecules. This compound is primarily needed by research and development chemists and process scale-up teams in the pharmaceutical and agrochemical industries for constructing complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorinated drug candidates where the fluorine atom enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging the fluorine atom to improve biological activity and environmental persistence.
• Liquid Crystal & OLED Material Research: Serves as a precursor in the synthesis of fluorinated organic electronic materials, where its structure contributes to desired dielectric and luminescent properties.
• Advanced Organic Synthesis: Employed in cross-coupling reactions, carbonyl chemistry, and as a scaffold for constructing more complex heterocyclic and polyfunctional aromatic compounds in R&D settings.
• Chemical Reference Standard: Supplied to analytical laboratories for use as a high-purity standard in method development and quality control testing for related compounds.

Basic Information

Item	Details
Product Name	2'-Fluoro-5'-Methylacetophenone
CAS No.	446-07-1
Molecular Formula	C9H9FO
Molecular Weight	152.17 g/mol
Synonyms	1-(2-Fluoro-5-methylphenyl)ethanone; 2-Fluoro-5-methylacetophenone; 2'-Fluoro-5'-Methyl Acetophenone; 1-Acetyl-2-fluoro-5-methylbenzene; 2-Fluoro-5-methylphenyl methyl ketone; α-Fluoro-m-methylacetophenone; 2-Fluoro-5-methyl-1-acetylbenzene
EINECS	Contact for details

Quality Control

Our 2'-Fluoro-5'-Methylacetophenone is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including chromatographic purity assays and structural confirmation, to ensure it meets the high standards required for research and industrial synthesis. A Certificate of Analysis (COA) detailing specific results for purity, identity, and impurities is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.