Description

5-Fluoroisatin is a versatile fluorinated heterocyclic building block, serving as a key intermediate in advanced organic synthesis. Its value lies in its unique molecular structure, which enables the efficient introduction of both fluorine and the isatin scaffold into target molecules, enhancing their biological activity and physicochemical properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated drug candidates, including kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Research: Used to develop novel fluorinated pesticides and herbicides, where the fluorine atom can improve metabolic stability and bioavailability.
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions and as a substrate for constructing complex heterocyclic frameworks.
• Biochemical Probe Development: Serves as a core structure for designing fluorescent probes and enzyme inhibitors used in biochemical assays.
• Material Science Research: Investigated as a monomer or precursor for synthesizing specialized polymers and organic electronic materials.

Basic Information

Product Name	5-Fluoroisatin
CAS No.	443-69-6
Molecular Formula	C8H4FNO2
Molecular Weight	165.12 g/mol
Synonyms	5-Fluoro-1H-indole-2,3-dione; 5-Fluoroindole-2,3-dione; 5-Fluoroisatin; 5-Fluoro-2,3-dioxoindoline; 5-Fluoro-2,3-indolinedione; 5-Fluoro-1H-indole-2,3-dione; 5-Fluorooxindole
EINECS	207-143-7

Quality Control

Our 5-Fluoroisatin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and NMR/IR for structural confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality for your critical synthesis work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	248 - 252 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.