Description

2,2,2-Trifluoro-1-(7-Methyl-3-Indolyl)Ethanone is a high-value fluorinated indole derivative, serving as a critical building block in advanced organic synthesis. Its unique trifluoroacetyl group attached to the indole scaffold makes it an essential intermediate for developing novel pharmaceuticals and agrochemicals with enhanced metabolic stability and bioavailability. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, due to the indole core's prevalence in bioactive molecules.
• Agrochemical Research: Used in developing new generation pesticides and herbicides, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Material Science: Serves as a monomer or functionalizing agent for creating specialty polymers and organic electronic materials with unique optical or electronic properties.
• Fluorine Chemistry: A valuable reagent for introducing the trifluoroacetyl moiety into complex molecules, facilitating structure-activity relationship (SAR) studies.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological development and exploring new chemical spaces in heterocyclic and fluoroorganic chemistry.

Basic Information

Product Name	2,2,2-Trifluoro-1-(7-Methyl-3-Indolyl)Ethanone
CAS No.	443-47-0
Molecular Formula	C11H8F3NO
Molecular Weight	227.18 g/mol
Synonyms	1-(7-Methyl-1H-indol-3-yl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(7-methyl-1H-indol-3-yl)ethanone; 7-Methyl-3-trifluoroacetylindole; 3-Trifluoroacetyl-7-methylindole; α,α,α-Trifluoro-7-methyl-3-indolyl methyl ketone; TFAMI; 443-47-0; NSC 406925
EINECS	Contact for details

Quality Control

Every batch of 2,2,2-Trifluoro-1-(7-Methyl-3-Indolyl)Ethanone is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay (HPLC), related substances, and physical characteristics. Our quality standards are designed to meet the rigorous demands of cGMP and ISO guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.