Description

(1-Bromo-2,2,2-Trifluoroethyl)Benzene is a versatile organofluorine and organobromine building block characterized by its reactive benzyl bromide and trifluoromethyl groups. This compound is valued for its ability to introduce both fluorine and bromine functionalities in a single synthetic step, enabling the construction of complex molecules with tailored properties. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for applications in cross-coupling reactions, nucleophilic substitutions, and as a precursor for liquid crystals.

Application

• Pharmaceutical Intermediate: Key synthon for the introduction of the trifluoroethyl moiety into active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting the central nervous system and metabolic diseases.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides and pesticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a crucial precursor in the synthesis of fluorinated liquid crystals for high-performance displays (LCDs).
• Organic Synthesis Building Block: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) and nucleophilic substitution reactions to create complex aromatic and heteroaromatic structures.
• Polymer Modification: Used to incorporate fluorine into polymer side chains, improving material properties such as chemical resistance, thermal stability, and surface characteristics.
• Fluorinated Surfactant & Coating Precursor: Acts as an intermediate for synthesizing specialty surfactants and surface treatment agents with low surface energy.

Basic Information

Product Name	(1-Bromo-2,2,2-Trifluoroethyl)Benzene
CAS No.	434-42-4
Molecular Formula	C8H6BrF3
Molecular Weight	239.03 g/mol
Synonyms	α-Bromo-α,α,α-trifluoroethylbenzene; 2-Bromo-1,1,1-trifluoro-2-phenylethane; Benzyl Bromide, α,α,α-trifluoro-; (2-Bromo-2,2,2-trifluoroethyl)benzene; 1-Phenylethyl Bromide, 2,2,2-trifluoro-; Trifluoromethylbenzyl Bromide; EINECS 207-105-7
EINECS	207-105-7

Quality Control

Our (1-Bromo-2,2,2-Trifluoroethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to the presence of a reactive carbon-bromine bond, it is recommended to store under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Refractive Index (n20D)	1.480 - 1.490
Density (20°C)	1.55 - 1.65 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.