Description

1,1,1-Trifluoro-3-Nitro-Butan-2-Ol CAS NO 434-39-9 is a versatile fluorinated nitro alcohol building block, prized for its unique trifluoromethyl and nitro functional groups. This compound is essential for introducing fluorine atoms into target molecules, significantly altering their physical, chemical, and biological properties. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel compounds with enhanced metabolic stability, lipophilicity, and bioactivity.

Application

• Pharmaceutical Intermediate: Key synthon for the development of fluorinated active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and CNS-targeted drug candidates.
• Agrochemical Synthesis: Used in creating advanced fluorinated pesticides, herbicides, and fungicides where the trifluoromethyl group improves efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, enhancing thermal stability and optical properties.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to produce specialty fluoropolymers with unique surface characteristics and chemical resistance.
• Organic Synthesis & Catalysis: A valuable reagent in asymmetric synthesis and as a building block for complex natural product analogs and chiral ligands.
• Energetic Materials Research: Investigated for potential use in the formulation of novel, high-performance fluorinated energetic compounds.

Basic Information

Product Name	1,1,1-Trifluoro-3-Nitro-Butan-2-Ol
CAS No.	434-39-9
Molecular Formula	C₄H₆F₃NO₃
Molecular Weight	173.09 g/mol
Synonyms	1,1,1-Trifluoro-3-nitrobutan-2-ol; 2-Nitro-1,1,1-trifluoro-3-butanol; 3-Nitro-1,1,1-trifluorobutan-2-ol; 1,1,1-Trifluoro-2-hydroxy-3-nitrobutane; 2-Butanol, 1,1,1-trifluoro-3-nitro-; 1,1,1-Trifluoro-3-nitro-2-butanol; TFNB; Trifluoromethyl nitro alcohol intermediate
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoro-3-Nitro-Butan-2-Ol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its light-sensitive and easily oxidized nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat, sparks, open flames, and incompatible materials such as strong oxidizing agents, strong bases, and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.