Description

1,1-Difluoroacetone is a versatile fluorinated ketone building block, valued for its unique reactivity profile conferred by the difluoromethyl group adjacent to the carbonyl. This compound is essential for introducing the difluoroacetone moiety into complex molecules, enabling the synthesis of novel materials and active ingredients. It is primarily sought by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for applications in fluorination chemistry and intermediate synthesis.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of fluorinated active pharmaceutical ingredients (APIs) and bioactive molecules.
• Agrochemical Synthesis: Used in the development of novel fluorinated pesticides and herbicides, where fluorine atoms can enhance biological activity and stability.
• Advanced Material Precursor: Serves as a monomer or building block for specialty polymers, coatings, and liquid crystals with tailored properties.
• Organic Synthesis Reagent: Employed in nucleophilic addition reactions and as a precursor for various heterocyclic compounds in research and development.
• Fluorine Chemistry Research: A valuable tool for studying the effects of gem-difluoro substitution on reaction pathways and molecular properties in academic and industrial labs.

Basic Information

Product Name	1,1-Difluoroacetone
CAS No.	431-05-0
Molecular Formula	C3H4F2O
Molecular Weight	94.06 g/mol
Synonyms	Difluoroacetone; 1,1-Difluoro-2-propanone; 1,1-Difluoropropan-2-one; 2-Propanone, 1,1-difluoro-; Acetone, 1,1-difluoro-; Gem-Difluoroacetone; DFA
EINECS	207-074-2

Quality Control

Our 1,1-Difluoroacetone is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We adhere to cGMP principles where applicable to support our customers' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases and reducing agents. Due to its highly volatile nature, keep containers tightly sealed and handle in a fume hood. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.