Description

2,2-Difluoroethylamine is a versatile organofluorine building block featuring a primary amine group on a difluoro-substituted ethane backbone. This compound is valued for its ability to introduce both fluorine atoms and a reactive amine handle into target molecules, enabling the fine-tuning of physicochemical properties. It is a critical intermediate for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel compounds with enhanced metabolic stability, lipophilicity, or biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorine-containing drugs for oncology, central nervous system (CNS) disorders, and anti-infectives.
• Agrochemical Synthesis: Used in the production of modern pesticides and herbicides, where the difluoroethylamine moiety can improve compound efficacy, environmental stability, and selectivity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in asymmetric synthesis and other advanced chemical transformations.
• Polymer & Material Science: Incorporated into monomers for the production of specialty polymers, such as fluorinated polyamides or polyurethanes, which may exhibit unique chemical resistance, thermal stability, or surface properties.
• Proteolysis Targeting Chimeras (PROTACs): A valuable linker component in the design of bifunctional PROTAC molecules for targeted protein degradation.
• Fluorinated Bioisostere: Employed in medicinal chemistry as a bioisostere for other functional groups to optimize the absorption, distribution, metabolism, and excretion (ADME) profiles of lead compounds.

Basic Information

Product Name	2,2-Difluoroethylamine
CAS No.	430-67-1
Molecular Formula	C2H5F2N
Molecular Weight	81.06 g/mol
Synonyms	2,2-Difluoroethanamine; 2,2-Difluoroethylamine Hydrochloride (salt form); 1-Amino-2,2-difluoroethane; Ethylamine, 2,2-difluoro-; NSC 92440; 2,2-Difluoro-1-ethylamine; α,α-Difluoroethylamine; DFEA
EINECS	207-074-8

Quality Control

Our 2,2-Difluoroethylamine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopic methods, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, purity, and impurity profiles is provided with every shipment. We support compliance with relevant regulatory frameworks for our customers' target markets.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to maintain stability and prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC/HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.