Description

Diethyl 2,2-Difluoropentanedioate is a high-purity fluorinated building block essential for advanced organic synthesis. This compound is valued for its role in introducing difluoromethylene groups, which are critical for modulating the physicochemical and metabolic properties of target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of fluorinated active pharmaceutical ingredients (APIs), where the difluoromethylene unit can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides that benefit from the unique properties of fluorine atoms.
• Material Science Research: Serves as a precursor for fluorinated polymers, liquid crystals, or specialty materials with tailored surface properties.
• Organic Synthesis Building Block: Employed in various carbon-carbon bond formation reactions, such as Michael additions or Reformatsky-type reactions, to construct complex fluorinated molecules.
• Fluorine Chemistry Studies: An important reagent for academic and industrial research focused on exploring new methodologies in organofluorine chemistry.

Basic Information

Product Name	Diethyl 2,2-Difluoropentanedioate
CAS No.	428-97-7
Molecular Formula	C9H14F2O4
Molecular Weight	224.20 g/mol
Synonyms	Diethyl 2,2-Difluoroglutarate; 2,2-Difluoropentanedioic Acid Diethyl Ester; Diethyl Difluoroglutarate; Ethyl 2,2-Difluoroglutarate; Glutaric Acid, 2,2-Difluoro-, Diethyl Ester; Diethyl 2,2-Difluoropentanedioate; 428-97-7; Ethyl 4-Ethoxy-2,2-difluoro-4-oxobutanoate
EINECS	Contact for details

Quality Control

Our Diethyl 2,2-Difluoropentanedioate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopy (NMR, IR), to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee consistency and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Refractive Index	1.410 - 1.420
Density	1.18 - 1.22 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.