Description

1,1,1-Trifluoro-2-Methyl-3-Nitropropan-2-Ol is a versatile fluorinated nitro alcohol building block of significant interest in advanced organic synthesis. Its unique structure, featuring both trifluoromethyl and nitro functional groups, makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for applications requiring the introduction of fluorine to modulate biological activity, lipophilicity, and metabolic stability.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides where the trifluoromethyl group enhances efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, improving thermal stability and optical properties.
• Polymer & Resin Modifier: Incorporated to create specialty polymers with enhanced chemical resistance, lower surface energy, and improved weatherability.
• Organic Synthesis Reagent: Employed in nucleophilic addition reactions and as a scaffold for constructing complex, polyfunctional molecules in medicinal chemistry research.
• Fluorine Chemistry Research: A valuable compound for academic and industrial research focused on new methodologies for introducing fluorinated motifs.

Basic Information

Product Name	1,1,1-Trifluoro-2-Methyl-3-Nitropropan-2-Ol
CAS No.	428-70-6
Molecular Formula	C4H6F3NO3
Molecular Weight	173.09 g/mol
Synonyms	2-Methyl-3-nitro-1,1,1-trifluoropropan-2-ol; 1,1,1-Trifluoro-2-methyl-3-nitro-2-propanol; 3-Nitro-1,1,1-trifluoro-2-methyl-2-propanol; 2-Propanol, 1,1,1-trifluoro-2-methyl-3-nitro-; α-(Trifluoromethyl)-α-methyl-β-nitroethanol; TFMNPO; Nitro-trifluoromethyl isobutyl alcohol derivative
EINECS	207-058-6

Quality Control

Our 1,1,1-Trifluoro-2-Methyl-3-Nitropropan-2-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and batch-to-batch consistency suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 2°C and 8°C for long-term stability. The container must be kept tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.