Description

2,2-Difluoromalonamide is a high-purity, specialized fluorinated building block essential for advanced organic synthesis. This compound is valued for its unique gem-difluoro moiety, which is strategically used to modulate the electronic and metabolic properties of target molecules. It is a critical intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients. Its precise structure enables the synthesis of complex fluorinated compounds with enhanced stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated active pharmaceutical ingredients (APIs), including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and production of modern, high-performance herbicides and pesticides with improved environmental profiles.
• Fluorinated Material Precursor: Serves as a building block for specialty polymers and advanced materials requiring fluorine incorporation for specific chemical resistance or surface properties.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for constructing complex molecules via reactions like nucleophilic substitution or condensation, leveraging the reactivity of the difluoromethylene group.
• Ligand and Catalyst Development: Useful in the design of novel fluorinated ligands for metal catalysis and organocatalysis.
• Life Science Research: Applied as a biochemical probe or tracer compound in metabolic and pharmacokinetic studies due to the fluorine label.

Basic Information

Product Name	2,2-Difluoromalonamide
CAS No.	425-99-0
Molecular Formula	C3H4F2N2O2
Molecular Weight	138.07 g/mol
Synonyms	2,2-Difluoropropanediamide; Difluoromalonamide; Malonamide, 2,2-difluoro-; Propanediamide, 2,2-difluoro-; 2,2-Difluoromalonic acid diamide; NSC 403697; AI3-52244
EINECS	Contact for details

Quality Control

Our 2,2-Difluoromalonamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, identity, and impurity profiles. We support our clients' regulatory needs and can provide material suitable for research and development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.