Description

3'-Fluoro-4'-Hydroxyacetophenone is a fluorinated aromatic ketone derivative that serves as a versatile and high-value synthetic intermediate in advanced organic chemistry. Its molecular structure, featuring both a phenolic hydroxyl group and a fluorine atom on the acetophenone core, makes it a critical building block for creating complex molecules with tailored properties. This compound is essential for research and development chemists and process engineers in the pharmaceutical and agrochemical industries, where it is used to synthesize active pharmaceutical ingredients (APIs) and novel crop protection agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Used to develop novel herbicides and pesticides, where the fluorine atom enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a building block for fluorinated liquid crystal compounds used in advanced display technologies.
• Polymer Chemistry: Acts as a monomer or modifier in the production of specialty polymers with enhanced thermal and chemical resistance.
• Organic Synthesis Research: A valuable reagent for academic and industrial R&D exploring new fluorination reactions and coupling methodologies.
• Fine Chemical Production: Employed in the multi-step synthesis of complex flavors, fragrances, and dyes.

Basic Information

Product Name	3'-Fluoro-4'-Hydroxyacetophenone
CAS No.	403-14-5
Molecular Formula	C8H7FO2
Molecular Weight	154.14 g/mol
Synonyms	1-(3-Fluoro-4-hydroxyphenyl)ethanone; 3-Fluoro-4-hydroxyacetophenone; 4'-Hydroxy-3'-fluoroacetophenone; 3-Fluoro-4-acetylphenol; 4-Acetyl-2-fluorophenol; 2-Fluoro-4-acetylphenol; FHHAP; 403-14-5
EINECS	Contact for details

Quality Control

Our 3'-Fluoro-4'-Hydroxyacetophenone is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the high standards required for pharmaceutical and fine chemical applications. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and consistent batch-to-batch quality.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flames. The compound is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	118°C - 122°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.