Description

4'-Fluoro-3'-Nitroacetophenone is a versatile and high-purity fluorinated aromatic ketone building block, essential for advanced organic synthesis. Its molecular structure, featuring both electron-withdrawing nitro and fluoro substituents, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated organic semiconductors and liquid crystal molecules, improving device performance.
• Dye & Pigment Intermediate: Employed in the production of specialized dyes and pigments, where the nitro and ketone groups facilitate chromophore formation.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Heck) for creating biaryl structures common in many functional materials.
• Chemical Research & Development: A valuable reagent for method development and exploring new reaction pathways in academic and industrial R&D laboratories.

Basic Information

Product Name	4'-Fluoro-3'-Nitroacetophenone
CAS No.	400-93-1
Molecular Formula	C8H6FNO3
Molecular Weight	183.14 g/mol
Synonyms	1-(4-Fluoro-3-nitrophenyl)ethanone; 3'-Nitro-4'-fluoroacetophenone; 4-Fluoro-3-nitroacetophenone; 1-Acetyl-4-fluoro-3-nitrobenzene; 4-Fluoro-3-nitroacetylbenzene; 3-Nitro-4-fluoroacetophenone; Ethanone, 1-(4-fluoro-3-nitrophenyl)-; FNAP
EINECS	206-935-5

Quality Control

Our 4'-Fluoro-3'-Nitroacetophenone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with agreed specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP and ISO 9001 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is light-sensitive and easily oxidized; for long-term storage, consider keeping under an inert atmosphere (e.g., nitrogen or argon) to maintain optimal purity and stability. Keep away from heat, sparks, open flames, and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	68°C - 72°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.