Description

2(3H)-Benzofuranone, Hexahydro-3A,6-Dihydroxy-4,4,7A-Trimethyl-, (3Ar,6R,7As)-Rel-(-)- (9Ci) is a high-purity, stereochemically defined lactone derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in its complex, functionalized structure which provides a versatile scaffold for constructing intricate molecular architectures, particularly in the pharmaceutical sector. This compound is essential for research chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries who require high-quality, optically active intermediates for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of complex drug candidates, particularly for central nervous system (CNS) and anti-inflammatory targets.
• Asymmetric Synthesis: Utilized as a starting material or advanced intermediate in catalytic asymmetric reactions to introduce stereocenters.
• Natural Product Synthesis: Serves as a core structural motif for the laboratory synthesis of natural products and their analogs.
• Agrochemical Research: Intermediate in the development of novel, optically active pesticides and herbicides.
• Flavor & Fragrance Chemistry: Potential precursor for the synthesis of specific lactone-based aroma compounds.
• Academic & Process R&D: Used in methodological studies and scale-up process development for chiral molecule manufacturing.

Basic Information

Product Name	2(3H)-Benzofuranone, Hexahydro-3A,6-Dihydroxy-4,4,7A-Trimethyl-, (3Ar,6R,7As)-Rel-(-)- (9Ci)
CAS No.	398119-19-2
Molecular Formula	C11H18O4
Molecular Weight	214.26 g/mol
Synonyms	(-)-Hexahydro-3a,6-dihydroxy-4,4,7a-trimethyl-2(3H)-benzofuranone; rel-(3aR,6R,7aS)-Hexahydro-3a,6-dihydroxy-4,4,7a-trimethyl-2(3H)-benzofuranone; (3aR,6R,7aS)-Hexahydro-3a,6-dihydroxy-4,4,7a-trimethyl-2-benzofuran-1(3H)-one; Optically Active Hexahydro Trimethyl Benzofuranone Diol; Chiral Lactone Diol Intermediate
EINECS	Contact for details

Quality Control

Every batch of this chiral intermediate is produced under strict quality management systems. We employ advanced analytical techniques including Chiral HPLC and NMR to ensure stereochemical purity and chemical identity. A comprehensive Certificate of Analysis (COA) detailing assay, enantiomeric excess, and impurity profiles is provided with each shipment, supporting cGMP-compliant development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.