Description

4A(4H)-Naphthalenecarboxaldehyde, 1,5,8,8A-Tetrahydro-2,5-Dimethyl-1,4-Dioxo-, (4Ar,5R,8As)-Rel- (9Ci) is a specialized chiral intermediate with a complex fused-ring structure, offering a unique stereochemical framework for advanced synthesis. This compound matters for its role as a key building block in the development of high-value, optically active pharmaceuticals and fine chemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors seeking to introduce specific stereocenters into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-infective drugs.
• Asymmetric Synthesis: Utilized as a starting material or reagent in catalytic asymmetric reactions to construct complex, enantiomerically pure molecules.
• Agrochemical Research: Employed in the development of new generation herbicides and pesticides where specific stereochemistry is crucial for bioactivity.
• Material Science: Potential use in creating chiral ligands for catalysis or as a monomer for specialty polymers with unique optical properties.
• Academic & Industrial R&D: A valuable tool for methodological development in organic chemistry and for exploring new chemical spaces in drug discovery programs.

Basic Information

Product Name	4A(4H)-Naphthalenecarboxaldehyde, 1,5,8,8A-Tetrahydro-2,5-Dimethyl-1,4-Dioxo-, (4Ar,5R,8As)-Rel- (9Ci)
CAS No.	395643-37-5
Molecular Formula	C₁₃H₁₆O₃
Molecular Weight	220.26 g/mol
Synonyms	rel-(4aR,5R,8aS)-1,5,8,8a-Tetrahydro-2,5-dimethyl-1,4-dioxo-4a(4H)-naphthalenecarboxaldehyde; (4aR,5R,8aS)-1,5,8,8a-Tetrahydro-2,5-dimethyl-1,4-dioxonaphthalene-4a(4H)-carbaldehyde; 4a(4H)-Naphthalenecarboxaldehyde, 1,5,8,8a-tetrahydro-2,5-dimethyl-1,4-dioxo-, (4aR,5R,8aS)-rel-; 395643-37-5; Chiral Naphthalene Dialdehyde Derivative
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and purity for sensitive synthetic applications. Quality is verified through comprehensive analytical techniques including HPLC, chiral analysis, and NMR spectroscopy. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, enantiomeric excess, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated place. Due to its sensitivity to light and oxidation, prolonged exposure to air or light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.