Description

1-(4-Bromo-2-Fluorophenyl)-3-Chloro-1-Propanone is a high-purity, halogenated aromatic ketone building block of significant interest in advanced organic synthesis. This compound matters because it serves as a critical intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, leveraging the bioactivity of the bromo-fluorophenyl moiety.
• Material Science Research: Serves as a precursor for synthesizing specialized monomers or ligands used in polymer and catalyst development.
• Chemical Biology Probes: Employed in the creation of molecular probes and tags for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	1-(4-Bromo-2-Fluorophenyl)-3-Chloro-1-Propanone
CAS No.	395639-63-1
Molecular Formula	C9H7BrClFO
Molecular Weight	265.51 g/mol
Synonyms	3-Chloro-1-(4-bromo-2-fluorophenyl)propan-1-one; 1-Propanone, 1-(4-bromo-2-fluorophenyl)-3-chloro-; 4'-Bromo-2'-fluoro-3-chloropropiophenone; 3-Chloro-1-(4-bromo-2-fluorophenyl)propanone; 1-(4-Bromo-2-fluorophenyl)-3-chloropropan-1-one
EINECS	Contact for details

Quality Control

Our 1-(4-Bromo-2-Fluorophenyl)-3-Chloro-1-Propanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber or opaque.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.