Description

(2-Aminophenyl)Boronic Acid Pinacol Ester Hydrochloride is a protected boronic acid derivative, a crucial building block in modern synthetic chemistry. Its value lies in its dual functionality, offering both a protected boronate group for Suzuki-Miyaura cross-coupling reactions and a primary amine group for further derivatization, all in a stable, crystalline hydrochloride salt form. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel active ingredients, particularly for creating complex biaryl and heterobiaryl structures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), especially those containing biphenyl or aryl-heteroaryl motifs.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air- and moisture-tolerant boronate ester coupling partner for palladium-catalyzed C-C bond formation.
• Ligand Synthesis: Used in the preparation of novel bidentate or tridentate ligands for catalysis, utilizing the amine for coordination or further functionalization.
• Material Science Research: Employed in the development of organic electronic materials, metal-organic frameworks (MOFs), and functional polymers.
• Agrochemical Development: Acts as a building block for creating new herbicides, fungicides, and insecticides with complex aromatic backbones.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or inhibitors for proteomics and diagnostic assay development.

Basic Information

Product Name	(2-Aminophenyl)Boronic Acid Pinacol Ester Hydrochloride
CAS No.	393877-09-3
Molecular Formula	C12H19BClNO2
Molecular Weight	255.55 g/mol
Synonyms	2-Aminophenylboronic Acid Pinacol Ester Hydrochloride; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)aniline Hydrochloride; 2-(Pinacolatoboryl)aniline Hydrochloride; (2-Aminophenyl)Pinacolboronate Hydrochloride; B-(2-Aminophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane Hydrochloride; 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine Hydrochloride; Aniline, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, hydrochloride
EINECS	Contact for details

Quality Control

Our (2-Aminophenyl)Boronic Acid Pinacol Ester Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring suitability for research and development use in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for prolonged manipulations to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.