Description

L-Proline, 4-Fluoro-5-Oxo-, Methyl Ester, (4R)- (9Ci) is a high-purity, non-natural amino acid derivative featuring a fluorinated pyrrolidine backbone. This compound is a critical chiral building block for pharmaceutical research and development, enabling the synthesis of novel bioactive molecules with enhanced metabolic stability and binding affinity. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries for the creation of peptide mimetics and targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, kinase inhibitors, and other small-molecule drug candidates.
• Peptidomimetics Research: Used to construct constrained peptide analogs where the fluorinated proline scaffold influences secondary structure and biological activity.
• Medicinal Chemistry: Serves as a versatile building block for structure-activity relationship (SAR) studies and lead optimization programs.
• Chemical Biology: Employed in the development of activity-based probes and molecular tools for studying enzyme function and protein-protein interactions.
• Process Chemistry: Used in the development and scale-up of synthetic routes for active pharmaceutical ingredients (APIs).
• Academic Research: A valuable reagent for universities and research institutes exploring new synthetic methodologies and fluorine chemistry.

Basic Information

Product Name	L-Proline, 4-Fluoro-5-Oxo-, Methyl Ester, (4R)- (9Ci)
CAS No.	393810-25-8
Molecular Formula	C7H10FNO3
Molecular Weight	175.16 g/mol
Synonyms	(4R)-4-Fluoro-5-oxo-L-proline methyl ester; Methyl (4R)-4-fluoro-5-oxo-L-prolinate; (R)-Methyl 4-fluoro-5-oxopyrrolidine-2-carboxylate; 4-Fluoro-5-oxo-L-proline methyl ester; L-4-Fluoro-5-oxoproline methyl ester; 393810-25-8; (4R)-4-Fluoro-5-oxoproline methyl ester
EINECS	Contact for details

Quality Control

Our L-Proline, 4-Fluoro-5-Oxo-, Methyl Ester, (4R)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.