Description

1-[2-Nitro-4-(Trifluoromethyl)Phenyl]-4-Methylpiperidine is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethyl and nitro-substituted aromatic structure. This compound is of significant commercial importance for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring specific fluorine chemistry. It is primarily sought by research organizations, fine chemical manufacturers, and pharmaceutical companies engaged in the development of new drugs, agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and other therapeutic areas.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, where the trifluoromethyl group can enhance biological activity and environmental stability.
• Material Science: Serves as a precursor for specialty polymers, liquid crystals, or advanced organic electronic materials due to its aromatic and fluorinated components.
• Chemical Synthesis: Employed in organic chemistry research for constructing complex piperidine-containing molecules and for studying nitration and fluorination reactions.
• Contract Research & Development (CRO/CMO): Supplied to organizations performing custom synthesis and process development for client projects.

Basic Information

Item	Detail
Product Name	1-[2-Nitro-4-(Trifluoromethyl)Phenyl]-4-Methylpiperidine
CAS No.	392237-31-9
Molecular Formula	C13H15F3N2O2
Molecular Weight	288.27 g/mol
Synonyms	4-Methyl-1-[2-nitro-4-(trifluoromethyl)phenyl]piperidine; 1-(2-Nitro-4-trifluoromethylphenyl)-4-methylpiperidine; 4-Methyl-1-(2-nitro-4-(trifluoromethyl)phenyl)piperidine; 392237-31-9; 4-Methyl-1-[2-nitro-4-(trifluoromethyl)phenyl]piperidine; Piperidine, 1-[2-nitro-4-(trifluoromethyl)phenyl]-4-methyl-
EINECS	Contact for details

Quality Control

Our production of 1-[2-Nitro-4-(Trifluoromethyl)Phenyl]-4-Methylpiperidine adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with customer specifications and relevant industry guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.