Description

4,4,5,5-Tetramethyl-2-(2-Methylbenzyl)-1,3,2-Dioxaborolane is a high-purity, organoboron reagent featuring a sterically hindered dioxaborolane structure. This compound is valued for its stability and reactivity as a key synthetic intermediate in advanced organic transformations. It is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and the synthesis of complex molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A crucial boron reagent for forming carbon-carbon bonds in the synthesis of biaryl compounds, a common scaffold in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Used in the research and development of novel drug candidates, particularly in constructing complex, sterically hindered molecular architectures.
• Agrochemical Research: Serves as a building block in the synthesis of new herbicides, fungicides, and insecticides with tailored properties.
• Material Science Precursor: Employed in the development of organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Biology & Proteomics: Can be utilized as a probe or tag in bioconjugation chemistry due to its selective reactivity.
• Academic & Industrial R&D: A versatile tool for methodological development in synthetic organic chemistry laboratories worldwide.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(2-Methylbenzyl)-1,3,2-Dioxaborolane
CAS No.	390381-02-9
Molecular Formula	C15H23BO2
Molecular Weight	246.15 g/mol
Synonyms	2-(2-Methylbenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (2-Methylbenzyl)boronic acid pinacol ester; 2-Methylbenzylboronic acid pinacol ester; o-Tolylmethylboronic acid pinacol ester; 1,3,2-Dioxaborolane, 2-[(2-methylphenyl)methyl]-4,4,5,5-tetramethyl-; Pinacol (2-methylbenzyl)boronate; B-(2-Methylbenzyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of 4,4,5,5-Tetramethyl-2-(2-Methylbenzyl)-1,3,2-Dioxaborolane adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and GC. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥95% (Typical 97-99%)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.