Description

2-(Methylsulfonyl)-1-[2-(Trifluoromethyl)Phenyl]Ethanone is a high-value, specialized organic intermediate featuring both a methylsulfonyl and a trifluoromethylphenyl moiety. This compound is critical for its role in facilitating complex molecular transformations, particularly in the synthesis of advanced pharmaceutical and agrochemical actives. It is primarily sought after by R&D chemists and process development scientists in the fine chemical and life sciences industries for constructing novel molecules with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammatory diseases, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Material Science Research: Serves as a precursor for advanced organic electronic materials, including charge-transport molecules and liquid crystals, due to its electron-withdrawing sulfone group.
• Cross-Coupling Reactions: Functions as a versatile electrophile or coupling partner in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) for constructing biaryl systems.
• Fluorine Chemistry: An important substrate for studying the influence of the trifluoromethyl group on reaction kinetics and molecular properties in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, complex intermediates.

Basic Information

Product Name	2-(Methylsulfonyl)-1-[2-(Trifluoromethyl)Phenyl]Ethanone
CAS No.	387350-34-7
Molecular Formula	C10H9F3O3S
Molecular Weight	266.24 g/mol
Synonyms	1-[2-(Trifluoromethyl)phenyl]-2-(methylsulfonyl)ethanone; 2-(Methylsulfonyl)-1-(2-trifluoromethylphenyl)ethanone; 2-(Methylsulphonyl)-1-[2-(trifluoromethyl)phenyl]ethanone; α-(Methylsulfonyl)-2-(trifluoromethyl)acetophenone; 387350-34-7; Ethanone, 2-(methylsulfonyl)-1-[2-(trifluoromethyl)phenyl]-
EINECS	Contact for details

Quality Control

Our production of 2-(Methylsulfonyl)-1-[2-(Trifluoromethyl)Phenyl]Ethanone adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical parameters. Our quality system is designed to meet the rigorous standards required for pharmaceutical development and other high-purity applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed and may require storage under an inert atmosphere for long-term preservation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.