Description

2-Iodo-1,4-Benzenedicarboxaldehyde is a versatile and highly functionalized aromatic building block, featuring both aldehyde and iodine substituents for selective cross-coupling and condensation reactions. This compound is critical for the synthesis of complex organic molecules, particularly in pharmaceutical research and advanced material science. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those requiring halogenated aromatic cores for further functionalization.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the iodine atom facilitates efficient coupling reactions.
• Ligand and Catalyst Development: Serves as a starting material for creating sophisticated chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the construction of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) due to its rigid, functionalizable backbone.
• Cross-Coupling Reactions: The iodine moiety makes it an excellent substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to form complex biaryl systems.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems.

Basic Information

Product Name	2-Iodo-1,4-Benzenedicarboxaldehyde
CAS No.	385416-64-8
Molecular Formula	C8H5IO2
Molecular Weight	276.03 g/mol
Synonyms	2-Iodoterephthalaldehyde; 1,4-Benzenedicarboxaldehyde, 2-iodo-; 2-Iodo-p-phthalaldehyde; Terephthalaldehyde, 2-iodo-; 2-Iodo-1,4-diformylbenzene; 2-Iodobenzene-1,4-dicarbaldehyde; 2-Iodoterephthalic aldehyde
EINECS	Contact for details

Quality Control

Our 2-Iodo-1,4-Benzenedicarboxaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP standards where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to minimize oxidation and degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.