Description

Difluoro-(3-Nitro-Phenoxy)-Acetic Acid Ethyl Ester is a specialized fluorinated aromatic ester building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both nitro and difluoroacetate functional groups, makes it a versatile precursor for constructing complex molecules with tailored properties. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated aromatic motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides, fungicides, and pesticides, where the nitro and fluorine substituents can contribute to biological activity and environmental persistence profiles.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated organic electronic materials, where its structure can influence dielectric anisotropy and luminescent properties.
• Organic Synthesis & Catalysis Research: Employed in methodological studies, such as cross-coupling reactions or nucleophilic aromatic substitutions, to explore new synthetic pathways.
• Fluorine Chemistry Studies: Acts as a model compound in academic and industrial research focused on the reactivity and applications of difluoroacetate esters.

Basic Information

Product Name	Difluoro-(3-Nitro-Phenoxy)-Acetic Acid Ethyl Ester
CAS No.	383670-91-5
Molecular Formula	C10H9F2NO5
Molecular Weight	261.18 g/mol
Synonyms	Ethyl 2,2-Difluoro-2-(3-nitrophenoxy)acetate; 2-(3-Nitrophenoxy)-2,2-difluoroacetic Acid Ethyl Ester; Ethyl Difluoro(3-nitrophenoxy)acetate; Acetic acid, 2,2-difluoro-2-(3-nitrophenoxy)-, ethyl ester; Ethyl α,α-Difluoro-α-(3-nitrophenoxy)acetate; 3-Nitrophenyl Difluoroacetate Ethyl Ester (common name); DFNPAE (abbreviation)
EINECS	Contact for details

Quality Control

Our Difluoro-(3-Nitro-Phenoxy)-Acetic Acid Ethyl Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key specifications such as assay purity and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.