Description

(αr,βs)-β-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-α-Hydroxy-4-(Phenylmethoxy)-Benzenepropanoic Acid Ethyl Ester is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. Its complex stereochemistry and protected functional groups make it a critical building block for the development of novel active pharmaceutical ingredients (APIs). This compound is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the synthesis of complex molecules, particularly in the fields of oncology and metabolic disease research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Serves as a protected amino acid derivative for constructing peptide analogs and mimetics in medicinal chemistry.
• Asymmetric Synthesis: Used as a starting material or intermediate in stereoselective chemical reactions to introduce specific chiral centers.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of target molecules.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs and CROs for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Item	Details
Product Name	(αr,βs)-β-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-α-Hydroxy-4-(Phenylmethoxy)-Benzenepropanoic Acid Ethyl Ester
CAS No.	382596-26-1
Molecular Formula	C23H29NO6
Molecular Weight	415.48 g/mol
Synonyms	(Ar,Bs)-Boc-Amino-Hydroxy-Benzyloxy Phenylpropanoate Ethyl Ester; Ethyl (3R,4S)-3-[(tert-Butoxycarbonyl)amino]-4-hydroxy-5-(phenylmethoxy)-5-phenylpentanoate; (3R,4S)-BocNH-CH(OH)-CH( CH2COOEt)-C6H4-OBn; BOC-Protected Amino Diol Ester Intermediate; 382596-26-1; tert-Butyl ((3R,4S)-4-hydroxy-1-(4-(benzyloxy)phenyl)-3-((ethoxycarbonyl)methyl)butyl)carbamate (related isomer); A Chiral β-Amino α-Hydroxy Acid Derivative.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency for critical R&D and cGMP manufacturing. Quality is verified through comprehensive analytical methods including HPLC for purity and chiral purity, NMR for structural confirmation, and MS for identity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting specifications for identity, assay, chiral purity, and related substances. We support compliance with ICH guidelines for impurity profiling.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.