Description

Cyclopropaneacetic Acid, 2-Carboxy-, α-Methyl Ester, (1S,2S)- (9Ci) is a high-purity, stereochemically defined chiral building block essential for advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures with precise three-dimensional control, a critical requirement in modern pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs) and novel therapeutic candidates. Its defined stereochemistry ensures the production of enantiomerically pure intermediates, directly impacting the efficacy and safety profile of the final drug molecule.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel Active Pharmaceutical Ingredients (APIs), particularly in central nervous system (CNS) and antiviral therapeutic areas.
• Asymmetric Synthesis: Employed in stereoselective reactions, including cyclopropanation, esterification, and cross-coupling, to introduce the constrained cyclopropane ring system.
• Agrochemical Research: Used in the synthesis of advanced, biologically active compounds for crop protection with potential insecticidal or herbicidal activity.
• Material Science Precursor: Serves as a specialized monomer or cross-linking agent in the development of polymers with unique thermal or mechanical properties.
• Chemical Biology Probe Development: Utilized to create molecular tools and probes for studying enzyme mechanisms and biological pathways due to its rigid, three-dimensional structure.
• Process Chemistry & Scale-up: Provides a reliable starting point for the optimization and kilogram-scale production of chiral intermediates under Current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Item	Details
Product Name	Cyclopropaneacetic Acid, 2-Carboxy-, α-Methyl Ester, (1S,2S)- (9Ci)
CAS No.	381678-75-7
Molecular Formula	C8H10O4
Molecular Weight	170.16 g/mol
Synonyms	(1S,2S)-2-(Methoxycarbonyl)cyclopropane-1-acetic acid; (1S,2S)-Methyl 2-(carboxymethyl)cyclopropanecarboxylate; (1S,2S)-Cyclopropane-1,2-diacetic acid α-methyl ester; (1S,2S)-1,2-Cyclopropanediacetic acid monomethyl ester; trans-(1S,2S)-Methyl hydrogen cyclopropane-1,2-diacetate; Chiral cyclopropane diester; (1S,2S)-CPDA methyl ester
EINECS	Contact for details

Quality Control

Every batch of Cyclopropaneacetic Acid, 2-Carboxy-, α-Methyl Ester, (1S,2S)- (9Ci) is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting critical parameters such as chiral purity (enantiomeric excess), chemical purity (by HPLC), and identity confirmation. Our quality commitment supports compliance with ISO guidelines and preparation for cGMP production environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents, strong bases, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e. (1S,2S)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.