Description

(2-Phthalimidomethylphenyl)Boronic Acid, Pinacol Ester is a high-value, organoboron building block specifically designed for advanced organic synthesis. This compound matters as a protected boronic acid derivative, offering enhanced stability and handling characteristics compared to its free acid form, which is critical for complex multi-step reactions. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel molecular architectures, particularly in Suzuki-Miyaura cross-coupling reactions.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for constructing biaryl and heterobiaryl motifs.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air-tolerant boronate ester reagent for palladium-catalyzed carbon-carbon bond formation, a cornerstone of modern medicinal chemistry.
• Agrochemical Synthesis: Used in the discovery and production of advanced crop protection agents and herbicides.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs or OFETs.
• Chemical Biology & Probe Development: Utilized for creating molecular probes and bioconjugates due to its selective reactivity.
• Process Chemistry & Scale-up: Its improved stability makes it suitable for optimizing and scaling synthetic routes from lab to pilot plant.

Basic Information

Product Name	(2-Phthalimidomethylphenyl)Boronic Acid, Pinacol Ester
CAS No.	380430-66-0
Molecular Formula	C21H22BNO4
Molecular Weight	363.22 g/mol
Synonyms	2-[(Phthalimidomethyl)phenyl]boronic acid pinacol ester; N-[(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl]phthalimide; (2-(Phthalimidomethyl)phenyl)boronic acid pinacol ester; 2-(Phthalimidomethyl)phenylboronic Acid Pinacol Ester; Pinacol [2-(Phthalimidomethyl)phenyl]boronate; Boronic acid, B-[2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]phenyl]-, pinacol ester; CAS 380430-66-0
EINECS	Contact for details

Quality Control

Our (2-Phthalimidomethylphenyl)Boronic Acid, Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.