Description

n-(4-Methoxybenzyl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is a high-purity, advanced pharmaceutical intermediate and versatile synthetic building block. This compound is valued for its role in facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern organic synthesis for creating complex carbon-carbon bonds. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially those containing biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific aromatic architectures.
• Material Science Research: Serves as a precursor for organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Medicinal Chemistry: Employed in the discovery and optimization of drug candidates through structure-activity relationship (SAR) studies.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to introduce an aniline-substituted phenylboronate ester group into molecular frameworks.
• Ligand and Catalyst Development: Can be used to synthesize novel ligands for metal catalysis or as a functional handle in polymer chemistry.

Basic Information

Product Name	n-(4-Methoxybenzyl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline
CAS No.	380152-01-2
Molecular Formula	C20H26BNO3
Molecular Weight	339.24 g/mol
Synonyms	3-((4-Methoxybenzyl)amino)phenylboronic acid pinacol ester; N-(4-Methoxybenzyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine; 3-[(4-Methoxybenzyl)amino]phenylboronic Acid Pinacol Ester; 2-[3-[(4-Methoxybenzyl)amino]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; B-[3-[(4-Methoxybenzyl)amino]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our n-(4-Methoxybenzyl)-3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Aniline is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and scale-up applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged manipulations to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.