Description

(3-Carboxy-5-Nitrophenyl)Boronic Acid, Pinacol Ester is a high-purity, multifunctional boronic ester building block essential for modern synthetic chemistry. Its core value lies in its dual functionality, offering both a protected boronic acid group and a carboxylic acid moiety, which enables precise cross-coupling and subsequent derivatization in complex molecule assembly. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for developing active ingredients, ligands, and functional polymers.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in oncology and CNS research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides that require specific aryl-boronate intermediates.
• Material Science: Serves as a monomer or functionalization agent in creating boron-containing polymers and organic electronic materials.
• Chemical Biology & Proteomics: Utilized in the synthesis of activity-based probes and inhibitors that target serine hydrolases and other enzymes.
• Ligand Synthesis: Acts as a precursor for creating sophisticated chelating ligands used in catalysis and metal-organic frameworks (MOFs).
• Academic & Contract Research: A valuable reagent for methodological development and exploring new chemical spaces in academic and CRO laboratories.

Basic Information

Item	Details
Product Name	(3-Carboxy-5-Nitrophenyl)Boronic Acid, Pinacol Ester
CAS No.	377780-80-8
Molecular Formula	C₁₃H₁₆BNO₆
Molecular Weight	293.08 g/mol
Synonyms	5-Nitro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid; 3-Carboxy-5-nitrophenylboronic Acid Pinacol Ester; 2-(3-Carboxy-5-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (3-Carboxy-5-nitrophenyl)boronic Acid Pinanediol Ester (common misnomer); B-(3-Carboxy-5-nitrophenyl)boronic Acid Pinacol Ester; Pinacol (3-Carboxy-5-nitrophenyl)boronate; CAS 377780-80-8.
EINECS	Contact for details

Quality Control

Every batch of (3-Carboxy-5-Nitrophenyl)Boronic Acid, Pinacol Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and development. A Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), identity confirmation, and impurity profile is supplied with each shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.