Description

(2-Bromomethylphenyl)Boronic Acid, Pinacol Ester is a versatile and high-value organoboron building block, specifically engineered for advanced synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern pharmaceutical and agrochemical development. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the boronic ester functionality for efficient coupling with heterocyclic chlorides.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of organic electronic materials, such as polymers for OLEDs and organic photovoltaics.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis or as a scaffold for creating novel organocatalysts.
• Chemical Biology Probes: Utilized in the synthesis of bioconjugates and molecular probes for studying biological pathways and protein functions.
• Scale-up Process Chemistry: Suitable for process optimization and pilot-scale manufacturing due to its stability under the pinacol ester protection, offering advantages over the free boronic acid.

Basic Information

Product Name	(2-Bromomethylphenyl)Boronic Acid, Pinacol Ester
CAS No.	377780-72-8
Molecular Formula	C₁₃H₁₈BBrO₂
Molecular Weight	297.00 g/mol
Synonyms	2-(Bromomethyl)benzeneboronic acid pinacol ester; (2-Bromobenzyl)boronic acid pinacol ester; 2-Bromobenzylboronic acid pinacol ester; 1-Bromo-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-ylmethyl)benzene; B-(2-Bromobenzyl)boronic acid pinacol ester; Pinacol (2-bromobenzyl)boronate; (2-Bromobenzyl)BPin; CAS 377780-72-8
EINECS	Contact for details

Quality Control

Every batch of (2-Bromomethylphenyl)Boronic Acid, Pinacol Ester is manufactured and tested under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to ensure identity, purity, and consistency meet the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic (moisture-sensitive) nature. Keep away from heat, sparks, and open flame. For long-term storage, consider desiccant in the secondary packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.