Description

3-(2,4,6-Trifluoro-Phenyl)-Propionaldehyde is a versatile fluorinated aromatic aldehyde building block, essential for introducing the 2,4,6-trifluorophenyl moiety into complex molecular architectures. Its high purity and consistent quality are critical for ensuring the success of downstream synthesis and final product performance in advanced research and manufacturing. This compound is primarily needed by pharmaceutical, agrochemical, and advanced materials research sectors for applications in drug discovery, crop protection, and specialty polymer development.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring a trifluoromethylphenyl group to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated mesogens and electron-transport materials, improving the performance and stability of display and lighting technologies.
• Cross-Coupling Reactions: An effective substrate in Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Organic Synthesis Building Block: Utilized in Grignard reactions, reductive amination, and condensation reactions to construct more complex aldehydes, alcohols, and amines.
• Fluorine-19 NMR Spectroscopy: Can be used as a reference standard or probe molecule in analytical chemistry and metabolic studies.

Basic Information

Product Name	3-(2,4,6-Trifluoro-Phenyl)-Propionaldehyde
CAS No.	377084-11-2
Molecular Formula	C9H7F3O
Molecular Weight	188.15 g/mol
Synonyms	3-(2,4,6-Trifluorophenyl)propanal; 2,4,6-Trifluorophenylpropionaldehyde; 3-(2,4,6-Trifluorophenyl)propionaldehyde; 1-(2,4,6-Trifluorophenyl)-3-propanal; 377084-11-2; 3-(Perfluorophenyl)propionaldehyde (incorrect but common); TFP-PA
EINECS	Contact for details

Quality Control

Every batch of 3-(2,4,6-Trifluoro-Phenyl)-Propionaldehyde undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. Our quality assurance protocol includes identity confirmation, purity assay, and impurity profiling. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.