Description

3-(2-Fluoro-6-Trifluoromethyl-Phenyl)-Propionic Acid Ethyl Ester is a high-value fluorinated aromatic ester building block, essential for advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethyl substituents, makes it a critical intermediate for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated compounds for electronic display technologies and organic light-emitting diodes (OLEDs).
• Advanced Polymer Chemistry: Employed as a monomer or modifier to introduce fluorine into polymer chains, improving chemical resistance, thermal stability, and surface properties.
• Chemical Research & Development: A versatile building block for exploring new reaction pathways and creating compound libraries in academic and industrial R&D settings.

Basic Information

Product Name	3-(2-Fluoro-6-Trifluoromethyl-Phenyl)-Propionic Acid Ethyl Ester
CAS No.	376641-10-0
Molecular Formula	C₁₂H₁₀F₄O₂
Molecular Weight	262.20 g/mol
Synonyms	Ethyl 3-(2-Fluoro-6-(trifluoromethyl)phenyl)propanoate; 2-Fluoro-α,α,α-trifluoro-o-toluic Acid Ethyl Ester (propanoate derivative); Ethyl 2-Fluoro-6-(trifluoromethyl)hydrocinnamate; 3-(2-Fluoro-6-trifluoromethylphenyl)propionic Acid Ethyl Ester; F-PTFMPA Ethyl Ester; 376641-10-0 (CAS); Aromatic Fluorinated Ester Building Block
EINECS	Contact for details

Quality Control

Every batch of 3-(2-Fluoro-6-Trifluoromethyl-Phenyl)-Propionic Acid Ethyl Ester is manufactured and tested under a strict quality management system. We guarantee high chemical purity and lot-to-lot consistency, which is critical for reproducible results in your synthesis workflows. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically by GC/HPLC), and impurity profiles is provided with each shipment to ensure full traceability and compliance with your internal quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.