Description

Ethyl (3S)-3-(4,4-Difluorocyclohexane-1-Carboxamido)-3-Phenylpropanoate is a high-purity, advanced pharmaceutical intermediate characterized by its chiral center and difluorocyclohexyl moiety. This compound matters as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting metabolic and central nervous system disorders. Pharmaceutical R&D and manufacturing organizations need it for developing next-generation therapeutics where precise stereochemistry and fluorination are key to drug efficacy and metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new chemical entities (NCEs) for various therapeutic areas.
• API Synthesis: Used in the multi-step synthesis of complex target molecules, leveraging its amide and ester functional groups for further derivatization.
• Drug Discovery & Medicinal Chemistry: Serves as a valuable scaffold for structure-activity relationship (SAR) studies, especially in programs exploring fluorinated compounds.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization for the commercial-scale production of candidate drugs.
• Biochemical Research: Potential use as a tool compound or precursor in probing enzyme interactions and metabolic pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring high stereochemical purity.

Basic Information

Product Name	Ethyl (3S)-3-(4,4-Difluorocyclohexane-1-Carboxamido)-3-Phenylpropanoate
CAS No.	376348-76-4
Molecular Formula	C18H23F2NO3
Molecular Weight	339.38 g/mol
Synonyms	(3S)-3-(4,4-Difluorocyclohexanecarboxamido)-3-phenylpropanoic acid ethyl ester; Ethyl (S)-3-(4,4-difluorocyclohexanecarboxamido)-3-phenylpropanoate; 376348-76-4; (S)-Ethyl 3-(4,4-difluorocyclohexane-1-carboxamido)-3-phenylpropanoate; 3-Phenylpropanoic acid, 3-[(4,4-difluorocyclohexyl)carbonyl]amino]-, ethyl ester, (3S)-; UNII-Contact for details; Ethyl (3S)-3-[(4,4-difluorocyclohexyl)formamido]-3-phenylpropanoate
EINECS	Contact for details

Quality Control

Our Ethyl (3S)-3-(4,4-Difluorocyclohexane-1-Carboxamido)-3-Phenylpropanoate is manufactured under strict quality management systems to ensure batch-to-batch consistency for critical R&D and scale-up work. Production adheres to ICH guidelines, and each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We support custom synthesis with specifications tailored to your process requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly closed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.