Description

Hexanoic Acid, 6-[(1,1-Dimethylethyl)Amino]-5-[[(1S)-2-Methoxy-1-Methyl-2-Oxoethyl]Amino]-6-Oxo-, Methyl Ester, (5R)- (9Ci) is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular architecture. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development and production of novel, high-value therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug molecules, especially those targeting specific biological pathways.
• API Synthesis: Used in the research, development, and scale-up production of new chemical entities (NCEs) and Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Serves as a chiral synthon for constructing molecules with defined stereochemistry, crucial for drug efficacy and safety.
• Process Chemistry & Optimization: Employed in route scouting and process development for more efficient and cost-effective manufacturing of target compounds.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs and CROs for custom synthesis projects and client-specific molecule production.
• Academic & Industrial Research: Used in medicinal chemistry programs for structure-activity relationship (SAR) studies and lead optimization.

Basic Information

Product Name	Hexanoic Acid, 6-[(1,1-Dimethylethyl)Amino]-5-[[(1S)-2-Methoxy-1-Methyl-2-Oxoethyl]Amino]-6-Oxo-, Methyl Ester, (5R)- (9Ci)
CAS No.	374936-69-3
Molecular Formula	C15H28N2O5
Molecular Weight	316.40 g/mol
Synonyms	(5R)-6-[(tert-Butyl)amino]-5-[[(2S)-2-methoxypropanoyl]amino]-6-oxohexanoic acid methyl ester; Methyl (5R)-6-[(tert-butyl)amino]-5-[[(2S)-2-methoxypropanoyl]amino]-6-oxohexanoate; (5R)-Methyl 6-((tert-butyl)amino)-5-(((S)-2-methoxypropanoyl)amino)-6-oxohexanoate; tert-Butyl-[(5R)-5-[[(1S)-2-methoxy-1-methyl-2-oxoethyl]amino]-6-methoxy-6-oxohexyl]carbamate (protected form variant); Advanced Pharmaceutical Intermediate 374936-69-3; Chiral Hexanoic Acid Derivative; Stereospecific Amino Acid Ester Intermediate.
EINECS	Contact for details

Quality Control

Our Hexanoic Acid, 6-[(1,1-Dimethylethyl)Amino]-5-[[(1S)-2-Methoxy-1-Methyl-2-Oxoethyl]Amino]-6-Oxo-, Methyl Ester, (5R)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the exacting standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.