Description

n-Boc-n-tert-Butyl-Glycine is a protected amino acid derivative of significant importance in advanced organic synthesis. This compound serves as a critical building block for the introduction of sterically hindered, tert-butyl-protected glycine moieties into complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel peptides, peptidomimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel peptide-based drugs and therapeutic agents.
• Peptidomimetic Research: Used to create modified peptide structures with enhanced metabolic stability and bioavailability.
• Solid-Phase Peptide Synthesis (SPPS): Employed as a protected amino acid derivative for the controlled assembly of custom peptide sequences.
• Medicinal Chemistry: Facilitates the exploration of structure-activity relationships (SAR) by incorporating a bulky, protected glycine analog into lead compounds.
• Chemical Biology: Useful in the synthesis of labeled or tagged peptides for proteomics and biochemical studies.
• Process Chemistry: Serves as a starting material or intermediate in the scalable production of specialized APIs.

Basic Information

Product Name	n-Boc-n-tert-Butyl-Glycine
CAS No.	374795-71-8
Molecular Formula	C₁₁H₂₁NO₄
Molecular Weight	231.29 g/mol
Synonyms	N-(tert-Butoxycarbonyl)-N-(tert-butyl)glycine; Boc-N(t-Bu)-Gly-OH; (tert-Butoxycarbonyl)(tert-butyl)aminoacetic acid; 2-[(tert-Butoxycarbonyl)(tert-butyl)amino]acetic acid; N-Boc-N-tert-butylglycine; N-Boc-N-t-butylglycine; Boc-N-tert-butyl-glycine; N-(tert-Butyl)-N-(tert-butoxycarbonyl)glycine
EINECS	Contact for details

Quality Control

Our n-Boc-n-tert-Butyl-Glycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, to ensure it meets the high standards required for research and pharmaceutical applications. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.