Description

3-Phenylisoxazole-5-Boronic Acid Pinacol Ester is a high-purity, organoboron building block essential for modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. This compound is critically needed by researchers and process chemists in pharmaceutical R&D, agrochemical discovery, and materials science for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing drug candidates containing the phenylisoxazole pharmacophore, which is prevalent in anti-inflammatory, antimicrobial, and CNS-active compounds.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific aryl-aryl linkages.
• Material Science Precursor: Serves as a building block for creating organic electronic materials, such as OLED emitters and charge-transport molecules, where the isoxazole moiety can tune electronic properties.
• Ligand & Catalyst Development: Employed in the synthesis of specialized ligands for transition metal catalysis or as a model substrate for catalyst screening and optimization.
• Chemical Biology Probe Synthesis: Facilitates the creation of tagged molecules and activity-based probes for studying biological pathways and protein function.
• Academic & Contract Research: A valuable reagent for methodological development in cross-coupling chemistry and the exploration of new chemical space in academic and CRO laboratories.

Basic Information

Product Name	3-Phenylisoxazole-5-Boronic Acid Pinacol Ester
CAS No.	374715-22-7
Molecular Formula	C15H18BNO3
Molecular Weight	271.12 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-phenylisoxazole; 3-Phenyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole; 3-Phenylisoxazole-5-boronic acid, pinacol ester; 3-Phenyl-5-(pinacolboronato)isoxazole; Pinacol 3-Phenylisoxazole-5-boronate; 3-Phenyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2-oxazole; Boronic acid, B-(3-phenyl-5-isoxazolyl)-, pinacol ester
EINECS	Contact for details

Quality Control

Our 3-Phenylisoxazole-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and consistent performance in cross-coupling reactions. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) for long-term storage and when dispensing to maintain stability and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.