Description

5-(1,3,2-Dioxaborinan-2-Yl)-3-Methylthiophene-2-Carboxaldehyde is a high-value organoboron building block, specifically a thiophene-based aldehyde bearing a cyclic dioxaborinane protecting group. This compound is essential for advanced organic synthesis, offering a stable and reactive handle for cross-coupling reactions and subsequent functionalization. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key electrophilic or nucleophilic partner for constructing biaryl and heterobiaryl systems prevalent in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate: Used in the synthesis of drug candidates targeting various therapeutic areas, leveraging the thiophene and aldehyde functionalities.
• Agrochemical Synthesis: Employed in the development of novel herbicides, fungicides, and insecticides where the thiophene moiety imparts specific biological activity.
• Organic Electronic Materials: Acts as a precursor for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs) and organic photovoltaics (OPVs).
• Ligand and Catalyst Development: Utilized to create novel bidentate or tridentate ligands for transition metal catalysis.
• Chemical Biology Probes: Facilitates the synthesis of labeled compounds or molecular probes for biochemical and diagnostic research.

Basic Information

Item	Detail
Product Name	5-(1,3,2-Dioxaborinan-2-Yl)-3-Methylthiophene-2-Carboxaldehyde
CAS No.	374537-98-1
Molecular Formula	C10H13BO3S
Molecular Weight	224.08 g/mol
Synonyms	3-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxaldehyde (common pinacol ester analog); 3-Methyl-5-(1,3,2-dioxaborinan-2-yl)thiophene-2-carbaldehyde; 2-Formyl-3-methyl-5-(1,3,2-dioxaborinan-2-yl)thiophene; 5-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-3-methylthiophene-2-carbaldehyde (alternative naming); Boronic ester of 3-methyl-2-formylthiophene-5-boronic acid
EINECS	Contact for details

Quality Control

Our 5-(1,3,2-Dioxaborinan-2-Yl)-3-Methylthiophene-2-Carboxaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with precise specifications. Certificates of Analysis (COA) documenting identity, purity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.