Description

2-Propenoic Acid, 3-[2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-, Methyl Ester, (2E)- is a high-value, advanced pharmaceutical intermediate and organic building block. This compound is specifically engineered for use in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern synthetic chemistry for forming carbon-carbon bonds. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require precise and reliable boronic ester reagents for constructing complex molecular architectures. The product is supplied to meet the stringent purity demands of research and development as well as scale-up production.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drug discovery programs targeting novel therapeutics.
• Agrochemical Synthesis: Used in the development of advanced crop protection agents and herbicides requiring specific aryl-aryl linkages.
• Organic Light-Emitting Diodes (OLEDs): Serves as a building block for creating sophisticated organic semiconductors and emissive layer materials.
• Polymer Chemistry: Employed in the synthesis of functionalized polymers and advanced materials with tailored properties.
• Ligand and Catalyst Development: Utilized for constructing complex ligand frameworks used in homogeneous catalysis.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D focused on palladium-catalyzed cross-coupling reactions.

Basic Information

Product Name	2-Propenoic Acid, 3-[2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]-, Methyl Ester, (2E)-
CAS No.	372193-92-5
Molecular Formula	C₁₆H₂₁BO₄
Molecular Weight	288.15 g/mol
Synonyms	(E)-Methyl 3-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acrylate; trans-2-Propenoic acid, 3-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, methyl ester; Methyl (E)-3-(2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acrylate; 2-Propenoic acid, 3-[2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-, methyl ester, (E)-; Boronic acid, B-[2-[(1E)-3-methoxy-3-oxo-1-propen-1-yl]phenyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management protocols. We guarantee high purity levels suitable for demanding synthetic applications, with comprehensive testing performed via HPLC, NMR, and GC to confirm identity, potency, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring full traceability and compliance with your internal quality standards and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.