Description

4,4-Difluoro-1-(4-Fluoro-Phenyl)-Butane-1,3-Dione is a high-purity fluorinated diketone building block of significant interest in advanced organic synthesis. Its value lies in its unique molecular scaffold, which serves as a versatile precursor for the development of complex heterocyclic compounds and active pharmaceutical ingredients (APIs). This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries seeking to incorporate difluoromethylene and aryl functionalities into novel molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated heterocycles, such as pyrazoles and isoxazoles, which are core structures in various drug discovery programs.
• Agrochemical Research: Used in developing novel active ingredients where the introduction of fluorine atoms can enhance biological activity, metabolic stability, and lipophilicity.
• Ligand & Catalyst Development: Serves as a precursor for β-diketone ligands used in coordination chemistry and catalysis, particularly for lanthanide and transition metal complexes.
• Material Science: Employed in the research of fluorinated organic electronic materials and polymers, where fluorine substitution can tune electronic properties and stability.
• Chemical Biology Probes: Useful for constructing fluorinated probes and tags for studying biological processes and enzyme mechanisms.

Basic Information

Product Name	4,4-Difluoro-1-(4-Fluoro-Phenyl)-Butane-1,3-Dione
CAS No.	371967-21-4
Molecular Formula	C10H7F3O2
Molecular Weight	216.16 g/mol
Synonyms	1-(4-Fluorophenyl)-4,4-difluorobutane-1,3-dione; 4,4-Difluoro-1-(4-fluorophenyl)-1,3-butanedione; 4-Fluorophenyl 4,4-difluoro-3-oxobutanoate (tautomer); 4,4-Difluoro-1-(p-fluorophenyl)-1,3-butanedione; p-Fluorophenyl difluorodiketone; DFPD; 371967-21-4
EINECS	Contact for details

Quality Control

Our 4,4-Difluoro-1-(4-Fluoro-Phenyl)-Butane-1,3-Dione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity building blocks for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is sensitive to strong alkalis and fluorides; keep away from incompatible substances. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.