Description

1H-Pyrano[3,4-C]Pyridine-5-Carbonitrile,6-Amino-3,4,7,8-Tetrahydro-7-Hydroxy-3,3-Dimethyl-8-Thioxo-(9Ci) is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring sophisticated molecular scaffolds. It is primarily sought by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective applications.
• Organic Synthesis Building Block: Utilized in research-scale and process chemistry for constructing fused pyrano-pyridine ring systems, which are privileged structures in medicinal chemistry.
• Chemical Research & Development: Serves as a standard or reference material in analytical method development and structure-activity relationship (SAR) studies.
• Agrochemical Research: Potential application as an intermediate in the development of new crop protection agents with novel modes of action.
• Material Science Exploration: Investigated for its potential utility in creating organic electronic materials or ligands for catalytic systems due to its electron-rich heterocyclic core.

Basic Information

Product Name	1H-Pyrano[3,4-C]Pyridine-5-Carbonitrile,6-Amino-3,4,7,8-Tetrahydro-7-Hydroxy-3,3-Dimethyl-8-Thioxo-(9Ci)
CAS No.	371780-31-3
Molecular Formula	C12H15N3O2S
Molecular Weight	265.33 g/mol
Synonyms	6-Amino-3,4,7,8-tetrahydro-7-hydroxy-3,3-dimethyl-8-thioxo-5H-pyrano[3,4-c]pyridine-5-carbonitrile; 6-Amino-7-hydroxy-3,3-dimethyl-8-thioxo-3,4,7,8-tetrahydro-5H-pyrano[3,4-c]pyridine-5-carbonitrile; 5H-Pyrano[3,4-c]pyridine-5-carbonitrile, 6-amino-3,4,7,8-tetrahydro-7-hydroxy-3,3-dimethyl-8-thioxo-; CAS 371780-31-3
EINECS	Contact for details

Quality Control

Our 1H-Pyrano[3,4-C]Pyridine-5-Carbonitrile intermediate is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements. Specifications are aligned with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C limits
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.