Description

2-Boc-1,2,3,4-Tetrahydroisoquinoline-6-Carbaldehyde (Wx622024) is a high-purity, protected aldehyde derivative of the tetrahydroisoquinoline scaffold, serving as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of complex pharmaceutical molecules, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing novel drug candidates and reference standards.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing the tetrahydroisoquinoline pharmacophore.
• Medicinal Chemistry Research: Used in hit-to-lead and lead optimization stages for constructing and diversifying compound libraries targeting various biological receptors.
• Process Chemistry Development: Serves as a starting material or intermediate in scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions for clinical trial material production.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group provides orthogonal protection for the amine functionality, enabling selective reactions on the aldehyde moiety during multi-step syntheses.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds or molecular probes for studying biological mechanisms and target engagement.
• Academic Research: Employed in university and institutional laboratories for methodological development and the exploration of new synthetic pathways in heterocyclic chemistry.

Basic Information

Item	Details
Product Name	2-Boc-1,2,3,4-Tetrahydroisoquinoline-6-Carbaldehyde (Wx622024)
CAS No.	371222-37-6
Molecular Formula	C15H19NO3
Molecular Weight	261.32 g/mol
Synonyms	6-Formyl-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 6-formyl-3,4-dihydro-1H-isoquinoline-2(2H)-carboxylate; 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxaldehyde; 2-Boc-6-formyl-1,2,3,4-tetrahydroisoquinoline; 2-Boc-THIQ-6-CHO; WX-622024; 371222-37-6; 2-N-Boc-1,2,3,4-tetrahydroisoquinoline-6-carbaldehyde
EINECS	Contact for details

Quality Control

Our 2-Boc-1,2,3,4-Tetrahydroisoquinoline-6-Carbaldehyde is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.