Description

5-(4-Nitro-Phenyl)-Isoxazole-3-Carboxylic Acid Ethyl Ester is a high-purity, specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound serves as a critical intermediate for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique isoxazole and nitro-phenyl motifs are leveraged. It is primarily sought by research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting inflammation, CNS disorders, or infectious diseases.
• Agrochemical Research: Used in the development of new herbicides, fungicides, or insecticides, exploiting the bioactive isoxazole scaffold.
• Chemical Biology Probe: Serves as a building block for creating molecular probes to study enzyme function or cellular pathways.
• Material Science Research: Potential intermediate for synthesizing specialty polymers or organic electronic materials with nitro-aromatic components.
• Academic & Contract Research: Employed in universities and CROs for methodological development and discovery chemistry projects.
• Custom Synthesis: A starting material for the contract manufacturing of bespoke, high-value fine chemicals for client-specific applications.

Basic Information

Product Name	5-(4-Nitro-Phenyl)-Isoxazole-3-Carboxylic Acid Ethyl Ester
CAS No.	370848-42-3
Molecular Formula	C12H10N2O5
Molecular Weight	262.22 g/mol
Synonyms	Ethyl 5-(4-Nitrophenyl)isoxazole-3-carboxylate; 5-(p-Nitrophenyl)isoxazole-3-carboxylic Acid Ethyl Ester; 3-Carbethoxy-5-(4-nitrophenyl)isoxazole; 370848-42-3; 5-(4-Nitrophenyl)-3-isoxazolecarboxylic Acid Ethyl Ester; Ethyl 5-(4-Nitrophenyl)-1,2-oxazole-3-carboxylate; 5-(4-Nitro-Phenyl)-Isoxazole-3-Carboxylic Acid Ethyl Ester
EINECS	Contact for details

Quality Control

Our 5-(4-Nitro-Phenyl)-Isoxazole-3-Carboxylic Acid Ethyl Ester is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality systems support development and cGMP-grade production as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0% (Area %)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.