Description

2-(Fmoc-Amino)-2-(1,1-Dioxo-4-Tetrahydrothiopyranyl)Acetic Acid is a sophisticated, non-proteinogenic amino acid derivative featuring a sulfone-protected thiol group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled introduction of cysteine analogs and facilitating advanced peptide engineering. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of therapeutic peptides, peptidomimetics, and complex biomolecules where precise side-chain functionality is required.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected intermediate for the incorporation of a sulfone-protected thianylglycine residue into peptide chains.
• Therapeutic Peptide Development: Used in the research and production of peptide-based pharmaceuticals targeting various diseases.
• Peptidomimetic Design: Serves as a scaffold for creating stable, bioavailable mimics of natural peptides.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme activity.
• Libraries for Drug Discovery: A valuable component in combinatorial chemistry for generating diverse peptide libraries for high-throughput screening.

Basic Information

Product Name	2-(Fmoc-Amino)-2-(1,1-Dioxo-4-Tetrahydrothiopyranyl)Acetic Acid
CAS No.	369402-98-2
Molecular Formula	C22H23NO6S
Molecular Weight	429.49 g/mol
Synonyms	Fmoc-Thianylglycine(SO2)-OH; 2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-2-(1,1-dioxo-1λ⁶-thian-4-yl)acetic acid; 4-(FmocNH-CHCOOH)-Tetrahydrothiopyran 1,1-Dioxide; Fmoc-4-Thianylglycine(SO2)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1,1-dioxo-1λ⁶-thian-4-ylglycine; Fmoc-Tpg(SO2)-OH; (R/S)-2-(Fmoc-amino)-2-(1,1-dioxo-tetrahydro-4-thiopyranyl)acetic acid
EINECS	Contact for details

Quality Control

Our production of 2-(Fmoc-Amino)-2-(1,1-Dioxo-4-Tetrahydrothiopyranyl)Acetic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity, essential for sensitive peptide synthesis. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to support your research and cGMP-compliant workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.