Description

4,4,5,5-Tetramethyl-2-(3-Methylbenzyl)-1,3,2-Dioxaborolane is a high-purity, organoboron reagent belonging to the class of pinacol boronic esters. This compound matters as a versatile and stable synthetic intermediate, crucial for modern cross-coupling reactions like the Suzuki-Miyaura coupling, which is fundamental to constructing complex molecules in research and development. It is primarily needed by pharmaceutical, agrochemical, and advanced material scientists for constructing carbon-carbon bonds and introducing functional groups with precision.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific aryl-alkyl linkages.
• Material Science: Serves as a precursor in the development of organic electronic materials, such as polymers for OLEDs and organic photovoltaics.
• Chemical Research & Development: An essential reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating complex organic structures.
• Ligand and Catalyst Preparation: Employed in the synthesis of specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Fine Chemical Production: Utilized in the manufacture of specialty chemicals, flavors, and fragrances where specific boronate esters are required.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(3-Methylbenzyl)-1,3,2-Dioxaborolane
CAS No.	365564-12-1
Molecular Formula	C14H21BO2
Molecular Weight	232.13 g/mol
Synonyms	(3-Methylbenzyl)boronic acid pinacol ester; 2-(3-Methylbenzyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-Methylbenzylboronic Acid Pinacol Ester; m-Tolylmethylboronic Acid Pinacol Ester; (m-Tolylmethyl)boronic Acid Pinacol Ester; 1-[(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)methyl]-3-methylbenzene; 365564-12-1; B-(3-Methylbenzyl)boronic Acid Pinacol Ester
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(3-Methylbenzyl)-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR and HPLC, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.